Ross P Holmes Selected Research

Hydroxyproline (4 Hydroxyproline)

1/2020	The effects of the inactivation of Hydroxyproline dehydrogenase on urinary oxalate and glycolate excretion in mouse models of primary hyperoxaluria.
1/2018	Hydroxyproline Metabolism and Oxalate Synthesis in Primary Hyperoxaluria.
1/2016	Metabolism of (13)C5-hydroxyproline in mouse models of Primary Hyperoxaluria and its inhibition by RNAi therapeutics targeting liver glycolate oxidase and hydroxyproline dehydrogenase.
12/2015	Hydroxyproline metabolism in a mouse model of Primary Hyperoxaluria Type 3.
3/2015	Proline dehydrogenase 2 (PRODH2) is a hydroxyproline dehydrogenase (HYPDH) and molecular target for treating primary hyperoxaluria.
3/2012	Metabolism of [13C5]hydroxyproline in vitro and in vivo: implications for primary hyperoxaluria.
3/2012	Hydroxyproline metabolism in mouse models of primary hyperoxaluria.
1/2011	Structural and biochemical studies of human 4-hydroxy-2-oxoglutarate aldolase: implications for hydroxyproline metabolism in primary hyperoxaluria.
3/2005	Mitochondrial hydroxyproline metabolism: implications for primary hyperoxaluria.

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Ross P Holmes Research Topics

Disease

22	Kidney Calculi (Kidney Stone) 01/2022 - 08/2002
14	Primary Hyperoxaluria (Oxaluria, Primary) 01/2020 - 11/2004
6	Hyperoxaluria (Oxaluria) 01/2020 - 08/2002
5	Primary hyperoxaluria type 1 01/2021 - 02/2008
4	Renal Insufficiency (Renal Failure) 01/2020 - 08/2006
3	Nephrocalcinosis 01/2020 - 08/2006
2	Calculi (Calculus) 07/2020 - 01/2012
2	Chronic Kidney Failure (Chronic Renal Failure) 01/2019 - 01/2017
2	Rare Diseases (Rare Disease) 01/2017 - 12/2016
2	Nephrolithiasis 05/2016 - 08/2006
2	Urolithiasis 03/2008 - 02/2007
1	Chronic Renal Insufficiency 01/2022
1	Crystalluria 07/2020
1	Autosomal Dominant Polycystic Kidney (ADPKD) 01/2019
1	Hypertrophy 01/2019
1	Disease Progression 01/2019
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2018
1	Hyperphagia (Overeating) 01/2017
1	Obesity 01/2017
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2017
1	Steatorrhea 01/2017
1	Calcium Oxalate Nephrolithiasis 02/2016
1	Cardiovascular Diseases (Cardiovascular Disease) 02/2016
1	Inborn Genetic Diseases (Disease, Hereditary) 03/2012
1	Infections 11/2011
1	Hepatocellular Carcinoma (Hepatoma) 07/2011
1	Body Weight (Weight, Body) 04/2009
1	Primary hyperoxaluria type 2 08/2006
1	Acute Kidney Injury (Acute Renal Failure) 09/2005

Drug/Important Bio-Agent (IBA)

29	OxalatesIBA 01/2022 - 08/2002
20	Calcium OxalateIBA 01/2021 - 10/2004
9	Hydroxyproline (4 Hydroxyproline)IBA 01/2020 - 03/2005
7	glyoxylic acid (glyoxylate)IBA 01/2020 - 03/2005
4	EnzymesIBA 01/2017 - 03/2005
3	CalciumIBA 01/2022 - 03/2008
3	Oxidoreductases (Dehydrogenase)IBA 01/2020 - 03/2015
3	glycollate oxidaseIBA 01/2017 - 02/2008
3	Alanine-glyoxylate transaminase (alanine-glyoxylate aminotransferase)IBA 01/2017 - 03/2012
3	4-hydroxy-2-oxoglutarate aldolaseIBA 12/2015 - 01/2011
3	glyoxylate reductaseIBA 10/2012 - 08/2006
2	glycolic acid (glycolate)IBA 01/2020 - 02/2008
2	Citric Acid (Citrate)FDA LinkGeneric 01/2019 - 03/2008
2	Glycine (Aminoacetic Acid)FDA LinkGeneric 07/2011 - 02/2008
1	SodiumIBA 01/2022
1	Proteins (Proteins, Gene)FDA Link 01/2022
1	PotassiumIBA 01/2022
1	Phosphates (Orthophosphate)IBA 07/2020
1	calcium phosphateIBA 01/2019
1	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 01/2019
1	Fatty Acids (Saturated Fatty Acids)IBA 01/2017
1	Dietary Fats (Dietary Fat)IBA 01/2017
1	Glyoxal (Ethanedial)IBA 02/2016
1	Pyridoxal Phosphate (Pyridoxal 5 Phosphate)IBA 01/2016
1	Small Interfering RNA (siRNA)IBA 01/2016
1	Proline Oxidase (Proline Dehydrogenase)IBA 03/2015
1	Hydroxypyruvate ReductaseIBA 03/2012
1	Anti-Bacterial Agents (Antibiotics)IBA 11/2011
1	A-factor (Streptomyces)IBA 11/2011
1	Phenylalanine (L-Phenylalanine)FDA Link 07/2011
1	GTP-Binding Proteins (G-Protein)IBA 04/2009
1	Flavin Mononucleotide (FMN)IBA 02/2008

Therapy/Procedure

3	Therapeutics 12/2016 - 01/2012
2	RNAi Therapeutics 01/2017 - 01/2016
2	Diet Therapy (Therapy, Diet) 02/2016 - 10/2013
1	Gastric Bypass (Roux-en-Y Gastric Bypass) 01/2017
1	Aftercare (After-Treatment) 11/2011
1	Nutrition Therapy (Medical Nutrition Therapy) 03/2008